The FLNA Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ABPX, Dilp2, Filamin A, FLN1, FLNA, OPD, OPD1, and XLVD. This antibody recognizes Human, and Mouse antigen. The FLNA Polyclonal Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene